PUBLICATIONS:

Lichti-Kaiser K, Xu C, Staudinger JL. Cyclic AMP-dependent protein kinase signaling modulates pregnane X receptor activity in a species-specific manner. Published online Jan 13. 2009 J Biol Chem. 2009 PMID: 19141612

Kristin Lichti-Kaiser and Jeff L. Staudinger. The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes. Drug Metab Dispos. 2008 Aug;36(8):1538-45. PMID: 18474680

Staudinger JL. Liver-enriched nuclear receptors: therapeutic opportunities. Mol Pharm. 2008 Jan-Feb;5(1):1-2. Editorial. PMID: 18247475

Staudinger JL, Lichti K. Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease. Mol Pharm. 2008 Jan-Feb;5(1):17-34. Review. PMID: 18159925

Bassan M, Liu H, Madsen KL, Armsen W, Zhou J, Desilva T, Chen W, Paradise A, Brasch MA, Staudinger J, Gether U, Irwin N, Rosenberg PA. Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. Eur J Neurosci. 2008 Jan;27(1):66-82. PMID: 18184314

Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S. Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clin Cancer Res. 13(8): 2488-2495, 2007. PMID: 17438109

H Huang, H Wang, M Sinz, M Zoeckler, J Staudinger, MR Redinbo, DG Teotico, J Locker, GV Kalpana, and S Mani. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.
Oncogene 26(2): 258-268, 2007. Epub 2006 Jul 3. PMID: 16819505

Anakk S, Huang, W, Staudinger JL, Tan K, Cole TJ, Moore DD, Stroble HW. "Gender dictates the nuclear receptor mediated regulation of CYP3A44." Drug Metab Dispos. 35: 36-42, 2007. PMID: 17020958

Jeff L. Staudinger, Xunshan Ding, and Kristin Lichti. Pregnane X receptor and natural products: Beyond Drug-drug Interactions. Expert Opin Drug Metab Toxicol. 2(6):847-857, 2006. PMID: 17125405

Ding X, Lichti K, Kim I, Gonzalez FJ, Jeff L. Staudinger. "Regulation of constitutive androstane receptor and its target genes by fasting, cyclic AMP, HNF-4 and the coactivator PGC-1 ." J Biol Chem. 281: 26540-26551, 2006. PMID: 16825189

Xunshan Ding, Kristin Lichti and Jeff L. Staudinger. "The Mycoestrogen Zearalenone Induces CYP3A through Activation of the Pregnane X Receptor." Toxicol. Sci. 91(2): 448-455, 2006. PMID:16547076

Ding Xunshan, Jeff L. Staudinger. "The Ratio of Constitutive Androstane Receptor to Pregnane X Receptor Determines the Activity of Guggulsterone against the Cyp2b10 Promotor." Jour. Of Pharm. and Exp. Ther. 314(1): 120-127, 2005. PMID: 15710363

Ding Xunshan, Jeff L. Staudinger. "Repression of PXR-mediated Induction of Hepatic CYP3A Gene Expression by Protein Kinase C." Biochem. Pharmacol. 69(5): 867-873, 2005. PMID: 15710363

Xunshan Ding and Jeff L. Staudinger. "Induction of Drug Metabolism by Forskolin, the Role of The Pregnane X Receptor and the PKA Signal Transduction Pathway." Jour. Of Pharm. and Exp. Ther. 2004 Sep; 321 (2): 1-8.

Xunshan Ding, Jeff L. Staudinger. "Repression of PXR-mediated Induction of Hepatic CYP3A Gene Expression by Protein Kinase C." Biochem. Pharmacol. 2005 Mar; 69 (5): 867-873.

Dan Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley, and Jeff L. Staudinger. "Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression Through the Pregnane X receptor." Jour. Of Pharm. and Exp. Ther. 2004 Aug;310(2):528-35.

Anakk S, Kalsotra A, Kikuta Y, Huang W, Zhang J, Staudinger JL, Moore DD, Strobel HW. "CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11." Pharmacogenomics J. 2004 Feb 10. 1-11.

Anakk S, Kalsotra A, Shen Q, Vu MT, Staudinger JL, Davies PJ, Strobel HW. "Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors." FASEB J. 17(12): 2003 Jul 03. 1736-8.

Chen C, Staudinger JL, Klaassen CD. "Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile." Drug Metab Dispos. 2003 Jul;31(7):908-15.

Staudinger, Jeff L., Ajay Madan, Kathleen M. Carol, and Andrew Parkinson "Regulation Of Drug Transporter Gene Expression By Nuclear Receptors." Drug Metab Dispos. 2003 May;31(5):523-7.

Grace L. Guo, Jeff Staudinger, Kenichiro Ogura, and Curtis D. Klaassen Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16 -carbonitrile Is via Interaction with Pregnane X Receptor. Mol Pharmacol. 2002 61: 832-839.

Staudinger, Jeff L., Bryan Goodwin, Stacey A. Jones, Diane Hawkins-Brown, Yaping Liu, Anne LaTour, Curtis D. Klaassen, Timothy M. Willson, Beverly H. Koller, and Steven A. Kliewer. "The Nuclear Receptor PXR Functions as a Hepatic Lithocholic Acid Sensor." Proc Natl Acad Sci, (2001) Mar 13; 98(6): 3369-3374.

Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterstrom, R. H., Perlmann, T., and Lehmann, J. M. "An orphan nuclear receptor activated by pregnanes defines a novel steroid-signaling pathway." Cell (1998) 92, 73-82.